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Neuron-like activation of microglia and astrocytes induces pro-inflammatory mediator expression including such as cytokines (interleukin (IL)-1, tumor necrosis factor (TNF)-, complementary components, acute-phase protein (Smith et al., 2012), which can stimulate inducible nitric oxide synthase (iNOS) and NO production with abnormal phagocytic activity (Lyman et al., 2014) (Figure 2)

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