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10.1186/s41065-025-00587-1 55 LiaoT.MaZ.LiuD.ShiL.MaoJ.WangP.et al (2024)

One 12 mg combined vial

MacMicking J, Xie QW, Nathan C

The topical drug, which is applied directly to inflamed skin, is now being tested in a multicenter clinical trial in patients with eczema

It also improves the skins radiance by reducing the lactic acid levels in the blood which further reduces blood pressure and improves blood circulation leaving the skin well-nourished and well fed with oxygen

Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)