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Press release: Safety, pharmacokinetics, and pharmacodynamics of CT-996, an oral small-molecule, signal-biased GLP-1 receptor agonist over 4 weeks in adults with obesity

10.1111/acel.13206 218 YangS.-G.ParkH.-J.KimJ.-W.JungJ.-M.KimM.-J.JegalH.-G.et al (2018)

The use of fluorescence resonance energy transfer-based biosensors of various GPCRs indicated the formation of distinct ligand-specific receptor conformations (Kim et al., 2022), and recent technical advances have revealed a far wider and more dynamic range of receptor and -Arr conformations that are ligand and receptor specific (Lee et al., 2016

10.1016/j.bbalip.2010.02.011 45 PamplonaR.DalfE.AyalaV.BellmuntJ.PratJ.FerrerI.et al

Aggregate 2 , 3547 (2021)

A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN