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The structural similarity between IGF1R and the insulin receptor means LR3 can be used to probe questions about cross-receptor signaling and the metabolic effects of IGF axis activation

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Thus, NCOA4 is recognized as a facilitator of ferroptosis, while HERC2 (an E3 ubiquitin ligase for NCOA4 and FBXL5), VAMP8 (involved in autophagosome-lysosome fusion), and C-MYC have the potential to influence ferritin autophagy by modulating NCOA4 expression
