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Indeed, iGPX4 may be a promising target for NAFLD therapy as activated iGPX4 interacts with the canonical cGPX4 by transforming cGPX4 from enzymatically active monomers to enzymatically inactive oligomers in response to lipid stress, which exacerbates ferroptosis (Tong et al., 2022)

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[DOI] [PubMed] [Google Scholar] 17.Rubino F.M., Verduci C., Giampiccolo R., Pulvirenti S., Brambilla G., Colombi A

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