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Costimulation serves as a mechanism to modulate the strength of the TCR signal and promote higher gene expression of immunomodulatory cytokines like interleukin-2, as well as other factors that facilitate T cell proliferation and differentiation ( A key mediator of T cell signaling is the divalent cation calcium (Ca 2+ )

A mutation in the LMNA gene or cellular stress such as UV exposure

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Glutathione agarose beads bind GST-fusion proteins (left), and Protein A, G, and L beads bind to antibodies

Lukes Medical Center- Houston and the Thomas Street HIV-Health Center

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