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The surge in levels of between 50-150% of free cortisol observed at the 30 minute time point is routinely used in the scientific field to assess adrenocortical activity and the correlation of the surge in cortisol levels post awakening to chronic stress, HPA axis dysfunction, and burnout are well established (Fries et al., 2009)

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Although, a normal cell has an appropriate pro-oxidantantioxidant balance, however, this balance can be shifted which may not favour the antioxidant system or when levels of antioxidants are diminished [45]

doi: 10.1093/jn/130.9.2200

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They were highly coordinated and successful, but those behind the production often laughed that the logistics and equipment necessary to make it happen could rival a Broadway show