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Collectively, these data suggest that OspC-mediated ADP-riboxanation of SEPT9 at Arg561 impairs salt bridges and disrupts the SEPT9-SEPT9 NC-interface, thereby preventing septin recruitment and S
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In Phase II metabolism, toxic doses of paracetamol can also be metabolized by conjugation with cysteine and mercapturic acid, forming additional safe metabolites that can be excreted from the body
Thiosulfate infusions also decrease cyanide toxicity but can cause accumulation of thiocyanate resulting in clinical toxicity
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