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In the body, bilirubin is excreted as waste, but bilirubin can serve as an antioxidant molecule, and the bilirubin-biliverdin redox couple has direct antioxidant function [80]

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IMiDs also produce therapeutic effects on several diseases by inhibiting TGF- 194 - 198

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

Late-phase research studying long-term effects or sustained outcomes may employ extended cycles with intensive tracking

Drug-Related Factors The molecular mechanisms that lead to induction of ADAs were initially related to the murine origin of the first mAbs, which were recognized as non-self by the human immune system