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In this respect, the dual agonist effect of tirzepatide seems to give it a superiority on semaglutide, with a greater decrease (more than 2%) in glycated hemoglobin (A1c), a marker of chronic hyperglycemia (Figure 4)

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10.1111/jgh.12751 101

Sham-operated rats were subjected to the same surgical procedure except for the MCA occlusion