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Normally, more than 99% of stored enzyme is secreted into the pancreatic duct and less than 1% diffuses across cell membranes and reaches the circulation via lymphatics and capillaries
PLoS Genet 9: e1003493
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The net direction of cholesterol flux is determined by the cholesterol concentration gradient (plasma membrane and HDL ratio of free cholesterol to phospholipid) (696) as well as by the phospholipid subspecies (697,698)
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