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During treatment of the PDX model of osteosarcoma, since the individuality of the mice, the tumor volume of one mouse reached 1500 mm 3 by the end of the treatment, and this mouse was not euthanized in time to obtain reliable and intuitive experimental results

The metabolic heterogeneity of cancer cells may result in failure of chemotherapy (Vasan et al., 2019)

A manual check of the title and abstract screening was then undertaken to identify studies considered relevant to the prespecified inclusion criteria

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The blocking effect of m11Fc was dose-dependent (Fig