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Endocr Rev 2018;39:990-1028.ArticlePubMed 24

Het systemische gevolg hiervan is een positieve feedback van hyperinsulinemie en een afname van de gevoeligheid van cellen voor glucose

[PubMed] [Google Scholar] [162].Baird L, Yamamoto M, The molecular mechanisms regulating the KEAP1-NRF2 pathway

Substantial evidence indicates that mutations in several PD-associated genes (e.g., LRRK2, GBA, PINK1, PRKN, *DJ-1*) and the expression of risk alleles such as APOE4 exert their pathological effects by disrupting autophagy-related pathways, notably the autophagy-lysosomal pathway and mitophagy (3)

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