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In vulnerable people, this can become a tipping point
[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Majumder A., Singh M., George A.K., Tyagi S.C
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It has, in fact already been proposed [7, 184] that oxidative stress is the pathogenic mechanism linking insulin resistance with dysfunction of both pancreatic beta-cells and the endothelium, eventually leading to overt diabetes and cardiovascular disease
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