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Combinational treatment of AUR and proteasome inhibitor (PI) synergistically led to catastrophic cell death, reversible by NAC or protein synthesis inhibitor CHX, yet refractory to blockade of apoptosis, necroptosis or ferroptosis
Markowitz et al, 1988
As D23 could potentially form hydrogen bond with the activator, the loss of activity observed in the mutant supported such a model
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10.1007/978-3-030-12457-1_25 78 KDIGO (2024)
