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ROS-induced ATG4 oxidation enhances LC3 lipidation and early autophagosome formation, 174 although phagophore growth can occur independently of LC3/ATG8

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Instead, a small pattern of genes mapping to innate immunity and antiviral activity required GSH for their induction

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Finally, a subset of ZIPs localized to intracellular membranes, such as ZIP7 in the ER, and ZIP9, ZIP11 and ZIP13 in the Golgi and ER, support organelle-specific zinc signaling, although their precise subcompartmental localizations remain areas of active investigation

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