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Ghiaur G, Lee DA, Imus PH, et al

If the cause can be identified, it'll help to determine the most appropriate treatment

Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

In rare cases, side effects may include allergic reactions, swelling, chest tightness, or difficulty breathing

8,15 Serum holotranscobalamin level, which is reduced in vitamin B 12 deficiency, compared favorably with homocysteine and methylmalonic acid levels as a confirmatory test in one study, but further trials are needed before its widespread use for this purpose can be recommended