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Therefore, targeting the Nrf2/ARE pathway represents a promising strategy to simultaneously address oxidative stress-induced neuronal dysfunction and the toxic proteinopathies characteristic of these disorders, offering hope for more effective treatments that modify disease progression rather than merely alleviating symptoms (Yang et al., 2025

Cycled therapy is common

Histological colon sections showed thickened submucosa due to inflammation, cell infiltration, and edema, confirming the UC model

SIBO and SIFO SIBO and SIFO disrupt the gastrointestinal balance (dysbiosis), often causing gas, bloating, and leaky gut

Additionally, it is essential to investigate and optimize the dosage and time point for NAD + boosting, as NAD + levels and the extent of depletion may vary between cell types

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