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The balance between acetyl-CoA and coenzyme A (or CoA) is determined by L-carnitine, which is instrumental in the conversion of acetyl-CoA to acetyl-L-carnitine, which can be then dissipated out of the mitochondria, thus avoiding the accumulation of acyl groups inside the mitochondria, which could be toxic

10.2337/db13-1677 Diabetes

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Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

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