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The role of SAM in nucleotide and protein methylation contributes to several epigenetic processes and points to the role of nutritional components, in this case methionine, in the control of gene expression

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The critical role of GCs in hepatic lipid metabolism is demonstrated in vivo by improvements in hepatic steatosis and normalization of hepatic triglyceride concentrations in a fatty liver mouse model after liver-specific GR disruption

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Differential metabolites in the plasma of the mice kept in the aforementioned two ambient temperatures were measured via ultra-high-performance liquid chromatography triple quadrupole mass spectrometry quadrupole time of flight mass spectrometry (UHPLC-QQQ/MS)