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Pb 2+ exposure impairs NMDA receptor function by interfering with its redox and voltage-dependent regulation, leading to reduced calcium influx critical for LTP and memory formation [67]

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Topical copper peptides primarily affect the epidermis and upper dermis, where penetration allows direct delivery

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"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo"

Savaskan NE, Borchert A, Brauer AU, Kuhn H