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2022;34(10) doi: 10.1002/adma.202106682

Mente A, de Koning L, Shannon HS, Anand SS

Conclusion: Our results suggest that the GSTM1, GSTT1 and GSTP1 genetic variations are not directly associated with the susceptibility to CAD in Iranian patients

Further mechanistic investigations revealed that hepatic DRP1 deficiency led to increased mtDNA levels and mitochondrial dysfunction, resulting in the activation of the cGAS-STING-interferon signaling pathway and exacerbating alcohol-induced liver injury