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10.1097/WNR.0000000000002074 391 WilliamsonW

These unstable intermediate complexes can undergo further chemical transformations into toxic dopamine-derived species, and such dopamine-quinone derivatives are well-documented to impair mitochondrial function and exert direct neurotoxic effects on SN dopaminergic neurons, contributing to their selective vulnerability in pathological states like PD (126)

Preparation of Compounds Labeled with Tritium and Carbon14 (John Wiley & Sons, 2009)

Thirdly, it should replicate key events, including the triggering of the NLRP3 inflammasome, the secretion of IL-1, and the infiltration of neutrophils, and present persistent inflammation and tissue destruction resulting from the dysregulation of the PCD network

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