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The FDA does not require pre-market approval for cosmetic ingredients the way it does for drugs, so a topical GHK-Cu product can be sold legally as a cosmetic without being an "FDA-approved" drug

Co-localization of erythropoietin mRNA and ecto-5-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin

Clin Oral Invest

Astrocytic reactivity reflects activation of complex molecularly defined programmes which define remodelling of biochemical, morphological, metabolic, and physiological properties of astroglia leading to an upregulation or loss of homoeostatic cascades, or in gain of new protective or regenerative functions

doi: 10.4137/CMO.S18006

Matas et al., 2024)