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Pickart & Margolina, Int J Mol Sci, 2018 Why it matters A peptide the body already makes

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Disruption of the glucagon receptor increases glucagon expression and granule populations in cells Our previous studies have shown that GCGR deficiency increases glucagon expression in zebrafish cells 16

A history of regulatory animal testing: what can we learn
Table 5 shows key studies demonstrating a role of IGF-1 signaling in the development of anemia
