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However, the potential impact on other adaptive immune cell subsets, including CD4 T cells and B cells, warrants further investigation

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Many of these models involve procedures that exploit the natural tendency for rodents to avoid environments that may be considered dangerous or threatening and, thereby, elicit an internal state of fear or anxiety (e.g., bright open spaces)

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PVD is closely related to inflammation, which plays a prominent role in atherosclerosis, the underlying cause of the disease, promoting endothelial injury and plaque formation