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doi: 10.1016/j.yexcr.2010.05.019

In parallel with tumor shrinkage, Erastin significantly upregulated the levels of 4-HNE, a lipid peroxidation marker, but not cleaved caspase-3 and Ki67, in LDHB KD tumors, reinforcing the notion that ferroptosis underpins the anti-tumor effects of SLC7A11 inhibition in LDHB KD cancer cells ( Supplementary Figure 9c, e )

209,213,214,215 Moreover, in Atox1 / mice, the expansion of extracellular matrix and neointimal formation were inhibited in response to vascular injury, accompanied by decreased accumulation of VSMCs in the neointima and reduced LOX activity

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Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

[DOI] [PubMed] [Google Scholar] Kwong M, Kan YW, Chan JY