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The practice's approach begins with thorough evaluation including detailed health history, physical examination, and appropriate diagnostic testing to identify healing barriers and optimize treatment protocols

There is a further complication

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To this aim, there has been a blooming effort in the development of potential CD38 inhibitors, which fall into different categories, such as small-molecule compounds, natural inhibitors, and antibody approaches

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doi: 10.1038/emboj.2009.128