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10.1016/j.semcancer.2017.11.001 Semin Cancer Biol

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In POTS, this signaling fails, leading to blood pooling in the lower extremities and a rapid, compensatory spike in heart rate

As mentioned earlier, they bioactivate AFB 1 to an electrophilic, highly reactive and unstable metabolite known as aflatoxin-8,9-epoxide, which binds to guanine residues in nucleic acids, leading to irreversible damage in DNA and causing hepatocarcinoma in humans, primates, and ducks [32], [84]

Due to their cholesterol sensing and anti-inflammatory activities, LXRs are considered as integrators of metabolic and inflammatory signaling (57)

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