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L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP

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132 In summary, whilst ApoB measurement cannot currently replace LDL-c and non-HDL-c, it is likely that its use will become more widespread as further evidence accumulates to inform thresholds and already there are particular clinical scenarios, in a specialist setting, when it would be of particular use including dysbetalipoproteinaemia, hypobetalipoproteinamia, abetalipoproteinaemia and dyslipidaemia associated with diabetes/obesity and conditions where lipoprotein X may be present

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The underlying mechanism has been attributed to MC4R-related signaling, which may support neuronal resilience and enhance regenerative potential after injury