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The agitation introduces air bubbles that create foam, and the foam-liquid interfaces generate shear stress that denatures the protein

BPC-157 is a stable gastric pentadecapeptide originally derived from human gastric juice, while TB-500 is a synthetic peptide modeled after the naturally occurring thymosin beta-4. KPV is a tripeptide fragment of alpha-melanocyte-stimulating hormone, and GHK-Cu is a naturally occurring copper-binding peptide