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There was a statistically significant difference found in the secondary outcome of the total hangover difference (NAC sumPlacebo sum) based on gender, with the female hangover difference of 3.5, and the male hangover difference of + 2 ( P = 0.04)

While such data come from informal sources and lack peer review, they raise concern over potential ocular toxicity

The notes below combine single-compound data and stack-specific considerations

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Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides

2020;18:55 Wang Y, Quan F, Cao Q, Lin Y, Yue C, Bi R, et al