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Aripirazole has a good safety profile and sulpiride and amisulpride are interesting options because they are not metabolised in the liver and have low risk of extrapyramidal symptoms, especially at lower doses

This may better aid the prediction/detection of human-relevant genotoxic aromatic amine metabolite release at an earlier stage in drug development, and help limit late candidate attrition

Almost none of them give the same careful attention to vitamin D, and that oversight may be quietly working against everything their protocol is

Wang Y, Harlin M, Larsen F, Wang X, et al

European Public Assessment Report

Many patients notice they fall asleep more easily and wake up feeling more refreshed