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This section will explore its potential role in IBD pathogenesis from the perspective of microbe-host interactions, elucidating the critical function of gut dysbiosis in the disease process

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When used in combination with the aromatase inhibitor letrozole, curcumin synergistically enhanced apoptosis and suppressed Bcl-2 expression in in vivo EC models, indicating its potential as a chemosensitizing agent (93, 94)

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Proc Natl Acad Sci U S A 99(21):1357113576

2.2 Abnormal amino acid antioxidant system System Xc , GSH, and GPX4 constitute a critical signaling axis in the regulation of intracellular lipid peroxidation and ferroptosis (Yu et al., 2025)