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The published research base is entirely preclinical (rat and mouse studies plus rat hippocampal neuron culture work)

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Blackman, A

Assessment of white matter loss using bond-selective photoacoustic imaging in a rat model of contusive spinal cord injury

Unlike oral and transdermal hormone therapies, which can produce rollercoaster hormone levels resulting in mood/energy fluctuations, pellet therapy is the only delivery method of hormone therapy that provides sustained hormone levels throughout the day without any fluctuations in energy or mood