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Systematic reviews conclude that a low serum concentration of vitamin D (VD) is linked to an increased risk of dementia and AD (Annweiler et al., 2013a

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In the structures of nickel or cobalt-activated IdeR complex with mbtA-mbtB operator DNA, two homodimers of IdeR are bound to the opposite side of the DNA duplex, forming a double-dimer complex, in which the DNA duplex adopts a distorted B -DNA conformation with three complete helical turns, and metal-binding sites 1 and 2 completely occupied (Fig

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