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The millimolar GSH intracellular concentrations, the low plasma micromolar concentrations and the low GSH redox potential ( E 0 = 240 mV) make GSH an ideal and perfect cellular redox buffer (Figure 2) (37), cell proliferation (37), and cell apoptosis (3842)

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Because experimental outcomes depend on model design, concentration selection, solvent system, controls, storage history, and analytical endpoints, all conclusions should be drawn only within the limits of the laboratory protocol

The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)
