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Vitamin B12 is water-soluble and excess amounts are normally excreted through urine, providing natural protection against toxicity

Andrews and colleagues (2009) demonstrated that MPTP-induced dopaminergic dysfunction is amplified in GHSR KO animals, and selective re-expression of GHSR1a in catecholaminergic neurons of GHSR KO animals reduced this degeneration

They solve different phases of the same problem: one repairs tissue at the site of injury, the other resets the inflammatory environment throughout the body