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mitochondrial damage glutathione and mitochondria Mitochondrial reactive oxygen species cause
Description
A recent genetic screen of genes complementing the loss of GPx4 in resistant cell lines uncovered new players for ferroptosis inhibition

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These non-hypoxic activation mechanisms are particularly relevant in inflammatory conditions such as osteomyelitis (Figure 2)

The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)

Many things can cause this burning feeling

Our results are consistent with the study by Shin et al
