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In addition, mitochondrial dysfunction, the underlying cause of many cancers, enhances resistance to apoptosis and fuels tumor progression by modifying energy redox homeostasis and cytochrome c release (Hsu et al

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and increase mitochondrial biogenesis by triggering AMP-activated protein kinase (AMPK)-induced peroxisome proliferator-activated receptor coactivator 1 (PGC-1) activation [52]

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Amino acids as nutrients, in particular leucine, arginine, and glutamine, are the most effective activators of mTORC1