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ISSN 2041-1723

doi: 10.14670/HH-11-853 37 FieuwsCBekJWPartonBDe NeefEDe WeverOHoorneMet al

The fact that pharmaceutical grade heroin and morphine already represent viable replacement strategies for heroin use disorder, suggests that also 6-MAM and M6G, or compounds that mimic their distinctive pharmacokinetic/pharmacodynamic profiles, should become the focus of research aimed at developing diversified and individualized treatment programs

In addition to MMPs, our study revealed significant upregulation of MPO , NOS , FN1 and HIF1 genes in the lung tissue of Hg-exposed rats

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