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The key strength of this study is that our patient population and study design are representative of a real-world clinical setting, including patients with various baseline HbA 1C concentration, weight, and BMI values who are taking other concomitant antihyperglycemic medications and have a history of prior GLP-1 RA and/or insulin use

It is especially true if researchers foresee long-term preservation

This study first aims to identify the neuronal correlates of tesofensine-induced weight loss in the Lateral Hypothalamus (LH) in lean and obese rats

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