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While fortification has helped reduce folate deficiency rates, vitamin B12 deficiency remains common because absorption challenges are often the primary issue rather than dietary intake alone
In addition, the UK guidelines prioritise the injections for individuals who have a particular need for them, for example people who have psychological barriers to taking pills every day

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Journal of Medicinal Chemistry, 57 (22), 9220-9231

In the REDEFINE 1 trial, 79.6% of combination participants experienced GI events versus 39.9% on placebo
