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[39]) were induced more than four-fold at 1 h and 9 h

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23A), formed as reaction by-products, limit the utility of BHT at high temperatures or under UV light because they generate new free radicals that perpetuate the kinetic chain reaction (Glin 2012)

Geromel et al., 2002)

Depletion of GSH is strongly implicated in many chronic degenerative diseases such as HIV, autoimmune disease, hypertension, cholesterol oxidation, myocardial infarction, glaucoma, hearing impairment, cataracts, macular degeneration, liver disease, cystic fibrosis, COPD, acute respiratory distress syndrome, asthma, many neurodegenerative disorders, and the aging process itself

In the phase 3 ELOQUENT-2 clinical trial in patients who had previously received one to three prior lines of therapy, PFS between groups favored elotuzumab with lenalidomide and dexamethasone versus lenalidomide and dexamethasone at 1 year (68% vs 57%) and 2 years (41% vs 27%)