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The first eight residues in the A 40 model have not been resolved in the PDB structure, they are added here assuming these residues to be in a random configuration

Acknowledgments I would like to express my deepest gratitude to the following individuals who have contributed to the completion of this article

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Supercritical CO 2 Extraction of Fingerroot Dried powder of fingerroot rhizome with moisture less than 3.5% w/w was extracted by supercritical carbon dioxide extraction

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The respective macrocycles were characterized in vitro by surface plasmon resonance (SPR) and all exhibited strong affinity to the Met ectodomain ( K D =219 nM