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Reduced methylation due to functional B12 deficiency results in depression, anxiety and poor sleep - common symptoms in CFS Reduced methylation due to functional B12 deficiency, results in lower production of melatonin and poor maturation of the gut Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyalitis (ME) is an ill defined disease that is characterized by a post exercise tiredness or malaise