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The absence of effects on IGF-1, glucose metabolism, and tissue growth means AOD-9604 avoids many common growth hormone side effects including edema, joint pain, glucose elevation, and concerns about cell proliferation

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Nonetheless, considering the clinical relevance of GLP-1 therapies and their potential impact on energy balance beyond food intake and body weight, future studies should investigate whether GLP-1 agonists influence hypothalamic neuropeptide expression or signaling cascades in MC4R-deficient models

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