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Oral glucose tolerance testing revealed that AOD-9604 has no negative impact on carbohydrate metabolism

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Functioning as a potent exercise mimetic, this small-molecule compound enhances mitochondrial function, fatty acid oxidation, and oxidative muscle fiber composition, thereby improving exercise endurance, cardiac metabolic efficiency, and systemic energy expenditure without increasing food intake 1-4

2021-2023: SURMOUNT Weight Management Program Four Phase 3 trials specifically evaluated weight reduction in participants without diabetes [3] : SURMOUNT-1: Pivotal 72-week trial (n=2,539) showing up to 22.5% total body weight loss with 15 mg dosethe highest weight loss ever reported for a pharmacological obesity intervention SURMOUNT-2: Obesity trial in participants with type 2 diabetes achieving 15.7% weight loss [5] SURMOUNT-3: Withdrawal study demonstrating 6.7% weight regain in placebo group vs