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When OGD/R-induced ROS production and iron accumulation were lessened, the occurrence of ferroptosis was prevented

For example, compounds like quercetin (found in apples and onions) and resveratrol (found in grapes) have been shown to inhibit the activation of NF-B, a master genetic switch that controls the expression of numerous inflammatory genes

Detailed mechanisms of the effects of these functional foods on the human organism still require further long-term clinical studies to confirm their safety of use, tolerability, indications, interactions, dosage, and, in particular, their specific impact on mental health

doi: 10.1152/ajpgi.00183.2013

The unique nature of ferroptosis, with its dependence on iron metabolism and vulnerability to lipid peroxidation, positions it as a pivotal player in the pathogenesis of liver diseases

& Yoo, Y