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p16 INK4a is a cell cycle inhibitor that blocks CDK4/6 activity, preventing cells from progressing from the G1 phase to the S phase of the cell cycle

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Chronic treatment with statins is associated with myopathy (Law and Rudnicka, 2006), a side-effect representing a broad clinical spectrum of disorders largely associated with a decrease in CoQ 10 levels and selenoprotein activity (Thompson et al., 2003